查看文章

Cellular activity in the brain depends on the high energetic support provided by mitochondria, the cell organelles which use energy sources to generate ATP^,,,. Acute cannabinoid intoxication induces amnesia in humans and animals^,, and the activation of type-1 cannabinoid receptors present at brain mitochondria membranes (mtCB₁) can directly alter mitochondrial energetic activity^,,. Although the pathological impact of chronic mitochondrial dysfunctions in the brain is well established^,, the involvement of acute modulation of mitochondrial activity in high brain functions, including learning and memory, is unknown. Here, we show that acute cannabinoid-induced memory impairment in mice requires activation of hippocampal mtCB₁ receptors. Genetic exclusion of CB₁ receptors from hippocampal mitochondria prevents cannabinoid-induced reduction of mitochondrial mobility, synaptic transmission and memory …