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Diabet. Med. 29, e377–e381 (2012)

Aims  Skeletal muscle is a major metabolic organ and plays important roles in glucose metabolism, insulin sensitivity and insulin action. Muscle telomere length reflects the myocyte’s exposure to harmful environmental factors. Leukocyte telomere length is considered a marker of muscle telomere length and is used in epidemiologic studies to assess associations with ageing‐related diseases where muscle physiology is important. However, the extent to which leucocyte and muscle telomere length are correlated is unknown, as are their relative correlations with glucose and insulin concentrations. The purpose of this study was to determine the extent of these relationships.

Methods  Leucocyte and muscle telomere length were measured by quantitative real‐time polymerase chain reaction in participants from the Malmö Exercise Intervention (n = 27) and the …