作者
Melanie M Ashton, Michael Berk, Chee H Ng, Malcolm Hopwood, Bianca Kavanagh, Lana J Williams, Jerome Sarris, Olivia M Dean
发表日期
2019/4/1
来源
BMJ open
卷号
9
期号
4
页码范围
e025640
出版商
British Medical Journal Publishing Group
简介
Introduction
First line pharmacological treatments for bipolar disorder (BD) can leave shortfalls in recovery leading to patients seeking alternative and adjunctive treatments such as nutraceuticals. This protocol for a systematic review and proposed meta-analysis aims to answer the research question: in patients with BD, how does use of nutraceutical treatments compare with placebo in reducing depressive and mania symptoms?
Methods and analysis
Clinical trials will be identified through database searches using PubMed via PubMed, EMBASE via embase.com, Cochrane Central Register of Controlled Clinical Trials (CENTRAL) via cochranelibrary.com and CINAHL Complete via EBSCO. Search terms for BD and specific nutraceuticals (75 total search terms) will be used. Double-blind, randomised, controlled, clinical trials of adults with BD will be included in the review. Risk of bias will be assessed using the …
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MM Ashton, M Berk, CH Ng, M Hopwood, B Kavanagh… - BMJ open, 2019