作者
BJ Tabner, S Turnbull, NJ Fullwood, M German, D Allsop
发表日期
2005/8/1
来源
Biochemical Society Transactions
卷号
33
期号
4
页码范围
548-550
出版商
Portland Press Ltd.
简介
By means of an ESR spin-trapping method, we have shown that Aβ (amyloid β), α-synuclein and various toxic forms of the prion protein all appear to generate H2O2 in vitro. A fundamental molecular mechanism underlying the pathogenesis of cell death in several different neurodegenerative diseases could be the direct production of H2O2 during the early stages of protein aggregation.
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