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To evaluate the dynamic changes of lymphocytes following transarterial radioembolization (TARE) for hepatocellular carcinoma (HCC) and their relationship to normal liver dose (NLD).

A total of 93 patients who underwent 102 treatments were retrospectively reviewed. Absolute lymphocyte counts pretreatment and at 1, 3, 6, and 12 months were evaluated. Kaplan–Meier, Spearman correlation, receiver operating characteristic (ROC) curve, and area under the curve (AUC) analyses were performed.

The mean absolute lymphocyte count at baseline was 1.25 ± 0.79 10³/µL which was significantly greater than 1 (0.71 ± 0.47 10³/µL, p<0.0001), 3 (0.79 ± 0.77 10³/µL, p=0.0003), and 6 (0.81 ± 0.44 10³/µL, p=0.0001) months, but not significantly different than 12 (0.92 ± 0.8 10³/µL, p=0.12) months post treatment. There was a modest negative correlation between NLD and …