作者
Annemijn H Jonkman, Glasiele C Alcala, Bertrand Pavlovsky, Oriol Roca, Savino Spadaro, Gaetano Scaramuzzo, Lu Chen, Jose Dianti, Mayson L de A Sousa, Michael C Sklar, Thomas Piraino, Huiqing Ge, Guang-Qiang Chen, Jian-Xin Zhou, Jie Li, Ewan C Goligher, Eduardo Costa, Jordi Mancebo, Tommaso Mauri, Marcelo Amato, Laurent J Brochard
发表日期
2023/7/1
期刊
American Journal of Respiratory and Critical Care Medicine
卷号
208
期号
1
页码范围
25-38
出版商
American Thoracic Society
简介
Rationale: Defining lung recruitability is needed for safe positive end-expiratory pressure (PEEP) selection in mechanically ventilated patients. However, there is no simple bedside method including both assessment of recruitability and risks of overdistension as well as personalized PEEP titration.
Objectives: To describe the range of recruitability using electrical impedance tomography (EIT), effects of PEEP on recruitability, respiratory mechanics and gas exchange, and a method to select optimal EIT-based PEEP.
Methods: This is the analysis of patients with coronavirus disease (COVID-19) from an ongoing multicenter prospective physiological study including patients with moderate-severe acute respiratory distress syndrome of different causes. EIT, ventilator data, hemodynamics, and arterial blood gases were obtained during PEEP titration maneuvers. EIT-based optimal PEEP was defined as the crossing point …
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