作者
Vivek L Patel, Evan L Busch, Tara M Friebel, Angel Cronin, Goska Leslie, Lesley McGuffog, Julian Adlard, Simona Agata, Bjarni A Agnarsson, Munaza Ahmed, Kristiina Aittomäki, Elisa Alducci, Irene L Andrulis, Adalgeir Arason, Norbert Arnold, Grazia Artioli, Brita Arver, Bernd Auber, Jacopo Azzollini, Judith Balmaña, Rosa B Barkardottir, Daniel R Barnes, Alicia Barroso, Daniel Barrowdale, Muriel Belotti, Javier Benitez, Birgitte Bertelsen, Marinus J Blok, Istvan Bodrogi, Valerie Bonadona, Bernardo Bonanni, Davide Bondavalli, Susanne E Boonen, Julika Borde, Ake Borg, Angela R Bradbury, Angela Brady, Carole Brewer, Joan Brunet, Bruno Buecher, Saundra S Buys, Santiago Cabezas-Camarero, Trinidad Caldes, Almuth Caliebe, Maria A Caligo, Mariarosaria Calvello, Ian G Campbell, Ileana Carnevali, Estela Carrasco, Tsun L Chan, Annie TW Chu, Wendy K Chung, Kathleen BM Claes, GEMO Study Collaborators, EMBRACE Collaborators, Jackie Cook, Laura Cortesi, Fergus J Couch, Mary B Daly, Giuseppe Damante, Esther Darder, Rosemarie Davidson, Miguel de la Hoya, Lara Della Puppa, Joe Dennis, Orland Díez, Yuan Chun Ding, Nina Ditsch, Susan M Domchek, Alan Donaldson, Bernd Dworniczak, Douglas F Easton, Diana M Eccles, Rosalind A Eeles, Hans Ehrencrona, Bent Ejlertsen, Christoph Engel, D Gareth Evans, Laurence Faivre, Ulrike Faust, Lídia Feliubadaló, Lenka Foretova, Florentia Fostira, George Fountzilas, Debra Frost, Vanesa García-Barberán, Pilar Garre, Marion Gauthier-Villars, Lajos Géczi, Andrea Gehrig, Anne-Marie Gerdes, Paul Gesta, Giuseppe Giannini, Gord Glendon, Andrew K Godwin, David E Goldgar, Mark H Greene, Angelica M Gutierrez-Barrera, Eric Hahnen, Ute Hamann, Jan Hauke, Natalie Herold, Frans BL Hogervorst, Ellen Honisch, John L Hopper, Peter J Hulick, KConFab Investigators, HEBON Investigators, Louise Izatt, Agnes Jager, Paul James, Ramunas Janavicius, Uffe Birk Jensen, Thomas Dyrso Jensen, Oskar Th Johannsson, Esther M John, Vijai Joseph, Eunyoung Kang, Karin Kast, Johanna I Kiiski, Sung-Won Kim, Zisun Kim, Kwang-Pil Ko, Irene Konstantopoulou, Gero Kramer, Lotte Krogh, Torben A Kruse, Ava Kwong, Mirjam Larsen, Christine Lasset, Charlotte Lautrup, Conxi Lazaro, Jihyoun Lee, Jong Won Lee, Min Hyuk Lee, Johannes Lemke, Fabienne Lesueur, Annelie Liljegren, Annika Lindblom, Patricia Llovet, Adria Lopez-Fernández, Irene Lopez-Perolio, Victor Lorca, Jennifer T Loud, Edmond SK Ma, Phuong L Mai, Siranoush Manoukian, Veronique Mari, Lynn Martin, Laura Matricardi
发表日期
2020/2/1
期刊
Cancer research
卷号
80
期号
3
页码范围
624-638
出版商
American Association for Cancer Research
简介
Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 3′ region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001-c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25–2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63–5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71–4.68; P = 0.00004) and elevated risk …
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VL Patel, EL Busch, TM Friebel, A Cronin, G Leslie… - Cancer research, 2020