作者
Marie-Annick Clavel, David Messika-Zeitoun, Philippe Pibarot, Shivani R Aggarwal, Joseph Malouf, Phillip A Araoz, Hector I Michelena, Caroline Cueff, Eric Larose, Romain Capoulade, Alec Vahanian, Maurice Enriquez-Sarano
发表日期
2013/12/17
期刊
Journal of the American College of Cardiology
卷号
62
期号
24
页码范围
2329-2338
出版商
American College of Cardiology Foundation
简介
Objectives
With concomitant Doppler echocardiography and multidetector computed tomography (MDCT) measuring aortic valve calcification (AVC) load, this study aimed at defining: 1) independent physiologic/structural determinants of aortic valve area (AVA)/mean gradient (MG) relationship; 2) AVC thresholds best associated with severe aortic stenosis (AS); and 3) whether, in AS with discordant MG, severe calcified aortic valve disease is generally detected.
Background
Aortic stenosis with discordant markers of severity, AVA in severe range but low MG, is a conundrum, unresolved by outcome studies.
Methods
Patients (n = 646) with normal left ventricular ejection fraction AS underwent Doppler echocardiography and AVC measurement by MDCT. On the basis of AVA-indexed-to-body surface area (AVAi) and MG, patients were categorized as concordant severity grading (CG) with moderate AS (AVAi >0.6 cm²/m² …
学术搜索中的文章
MA Clavel, D Messika-Zeitoun, P Pibarot, SR Aggarwal… - Journal of the American College of Cardiology, 2013