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This study compared the ability of two sodium fluoride dentifrices, one containing 5,000 ppm fluoride (Prevident 5000 Plus) and the other 1,100 ppm fluoride (Winterfresh Gel), to reverse primary root caries lesions (PRCLs). A total of 201 subjects with at least one PRCL each entered the study and were randomly allocated to use one of the dentifrices. After 6 months, 186 subjects were included in statistical analyses. At baseline and after 3 and 6 months, the lesions were clinically assessed and their electrical resistance measured using an electrical caries monitor. After 3 months, 39 (38.2%) of the 102 subjects in the 5,000 ppm F^– group and 9 (10.7%) of 84 subjects using the 1,100 ppm F^– dentifrice, had one or more PRCLs which had hardened (p = 0.005). Between baseline and 3 months, the log₁₀ mean ± SD resistance values of lesions for subjects in the 1,100 ppm F^– group had decreased by 0.06±0.55 …