作者
Yun R Li, Jessica van Setten, Shefali S Verma, Yontao Lu, Michael V Holmes, Hui Gao, Monkol Lek, Nikhil Nair, Hareesh Chandrupatla, Baoli Chang, Konrad J Karczewski, Chanel Wong, Maede Mohebnasab, Eyas Mukhtar, Randy Phillips, Vinicius Tragante, Cuiping Hou, Laura Steel, Takesha Lee, James Garifallou, Toumy Guettouche, Hongzhi Cao, Weihua Guan, Aubree Himes, Jacob van Houten, Andrew Pasquier, Reina Yu, Elena Carrigan, Michael B Miller, David Schladt, Abdullah Akdere, Ana Gonzalez, Kelsey M Llyod, Daniel McGinn, Abhinav Gangasani, Zach Michaud, Abigail Colasacco, James Snyder, Kelly Thomas, Tiancheng Wang, Baolin Wu, Alhusain J Alzahrani, Amein K Al-Ali, Fahad A Al-Muhanna, Abdullah M Al-Rubaish, Samir Al-Mueilo, Dimitri S Monos, Barbara Murphy, Kim M Olthoff, Cisca Wijmenga, Teresa Webster, Malek Kamoun, Suganthi Balasubramanian, Matthew B Lanktree, William S Oetting, Pablo Garcia-Pavia, Daniel G MacArthur, Paul IW de Bakker, Hakon Hakonarson, Kelly A Birdwell, Pamala A Jacobson, Marylyn D Ritchie, Folkert W Asselbergs, Ajay K Israni, Abraham Shaked, Brendan J Keating
发表日期
2015/12
期刊
Genome medicine
卷号
7
页码范围
1-13
出版商
BioMed Central
简介
Background
In addition to HLA genetic incompatibility, non-HLA difference between donor and recipients of transplantation leading to allograft rejection are now becoming evident. We aimed to create a unique genome-wide platform to facilitate genomic research studies in transplant-related studies. We designed a genome-wide genotyping tool based on the most recent human genomic reference datasets, and included customization for known and potentially relevant metabolic and pharmacological loci relevant to transplantation.
Methods
We describe here the design and implementation of a customized genome-wide genotyping array, the ‘TxArray’, comprising approximately 782,000 markers with tailored content for deeper capture of variants across HLA, KIR, pharmacogenomic, and metabolic loci important in transplantation. To test concordance and …
学术搜索中的文章
YR Li, J van Setten, SS Verma, Y Lu, MV Holmes… - Genome medicine, 2015