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Lead‐ (Pb‐) induced hypertension has been shown in humans and experimental animals and cardiovascular effects of hydrogen sulfide (H₂S) have been reported previously. However, no studies examined involvement of H₂S in Pb‐induced hypertension. We found increases in diastolic blood pressure and mean blood pressure in Pb‐intoxicated humans followed by diminished H₂S plasmatic levels. In order to expand our findings, male Wistar rats were divided into four groups: Saline, Pb, NaHS, and Pb + NaHS. Pb‐intoxicated animals received intraperitoneally (i.p.) 1st dose of 8 μg/100 g of Pb acetate and subsequent doses of 0.1 μg/100 g for seven days and sodium hydrosulfide‐ (NaHS‐) treated animals received i.p. NaHS injections (50 μmol/kg/twice daily) for seven days. NaHS treatment blunted increases in systolic blood pressure, increased H₂S plasmatic levels, and diminished whole‐blood lead …