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Stroke is a leading cause of disability and dependence on the family, specifically daughter caregivers. The quality of the parent–child relationship can influence the experiences and well-being of daughters. Little is known about this in the context of stroke caregiving. We aimed to explore daughters’ perceptions of changes in the relationship with their parent and how these changes contribute to their well-being. We used a qualitative descriptive design. Twenty-three daughters completed one in-depth interview that was transcribed, reviewed, coded, and categorized to generate themes. The parent–child relationship was central to each of the three themes: It (a) led daughters to take on the caregiving role, (b) changed as a result of caregiving, and (c) contributed to daughters’ physical and emotional health. Targeted counseling that addresses changes in the parent–child relationship can help mitigate losses in …