作者
R Scarpa, R Alaggio, Lorenzo Norberto, J Furmaniak, S Chen, B Rees Smith, S Masiero, L Morlin, Mario Plebani, Filippo De Luca, MC Salerno, Roberta Giordano, G Radetti, Lucia Ghizzoni, G Tonini, Fabio Farinati, Corrado Betterle
发表日期
2013/2/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
98
期号
2
页码范围
704-712
出版商
Oxford University Press
简介
Background
Autoantibodies to tryptophan hydroxylase (TPHAbs) directed against serotonin-producing enterochromaffin cells (EC) have been reported in autoimmune-polyendocrine-syndrome type 1 (APS-1) patients with gastrointestinal dysfunction (GID). Serotonin plays a critical role in enteric function and its peripheral blood levels reflect serotonin release from the gastrointestinal tract.
Aims
We test the hypothesis that TPHAbs mark a distinct autoimmune component of APS-1 characterized by an autoimmune attack toward EC, which results in clinical GID.
Methods
TPHAbs were measured in 64 APS-1 patients. Endoscopy with gastric (antrum/body) and duodenal biopsy was carried in 16 TPHAbs+ patients (8 with and 8 without GID) and in 2 TPHAbs− patients (without GID). Immunohistochemistry of biopsy specimens was carried out using antibodies to …
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R Scarpa, R Alaggio, L Norberto, J Furmaniak, S Chen… - The Journal of Clinical Endocrinology & Metabolism, 2013