作者
Corrado Betterle, Riccardo Scarpa, Silvia Garelli, Luca Morlin, Francesca Lazzarotto, Fabio Presotto, Graziella Coco, Stefano Masiero, Anna Parolo, Maria Paola Albergoni, Roberta Favero, Susi Barollo, Monica Salva, Daniela Basso, Shu Chen, Bernard Rees Smith, Jadwiga Furmaniak, Franco Mantero
发表日期
2013/12
期刊
European journal of endocrinology
卷号
169
期号
6
页码范围
773-784
出版商
Oxford University Press
简介
Objective
Addison's disease (AD) is a rare endocrine condition.
Design
We aimed to evaluate clinical, immunologic, adrenal imaging, and genetic features in 633 Italian patients with AD followed up since 1967.
Methods
Adrenal cortex autoantibodies, presence of other autoimmune and nonautoimmune diseases, nonadrenal autoantibodies, adrenal imaging, and genetic profile for HLA-DRB1 and AIRE were analyzed.
Results
A total of 492 (77.7%) patients were found to be affected by autoimmune AD (A-AD), 57 (9%) tuberculous AD, 29 (4.6%) genetic-associated AD, 10 (1.6%) adrenal cancer, six (0.94%) post-surgical AD, four (0.6%) vascular disorder-related AD, three (0.5%) post-infectious AD, and 32 (5.1%) were defined as idiopathic. Adrenal cortex antibodies were detected in the vast majority (88–100%) of patients with recent …
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C Betterle, R Scarpa, S Garelli, L Morlin, F Lazzarotto… - European journal of endocrinology, 2013