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The stimulation of inhibitory neurotransmitter receptors, such as γ‐aminobutyric acid type B (GABA_B) receptors, activates G protein‐gated inwardly‐rectifying K⁺ (GIRK) channels, which influence membrane excitability. There is now evidence suggesting that G protein‐coupled receptors and G protein‐gated inwardly‐rectifying K⁺ [GIRK/family 3 of inwardly‐rectifying K⁺ (Kir3)] channels do not diffuse freely within the plasma membrane, but instead there are direct protein–protein interactions between them. Here, we used bioluminescence resonance energy transfer, co‐immunoprecipitation, confocal and electron microscopy techniques to investigate the oligomerization of GABA_B receptors with GIRK channels containing the GIRK3 subunit, whose contribution to functional channels is still unresolved. Co‐expression of GABA_B receptors and GIRK channels in human embryonic kidney‐293 cells in combination …