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Although dendritic cells (DCs) play an important role in mediating protection against influenza virus, the precise role of lung DC subsets, such as CD11b⁻ and CD11b⁺ conventional DCs or plasmacytoid DCs (pDCs), in different lung compartments is currently unknown. Early after intranasal infection, tracheal CD11b⁻CD11c^hi DCs migrated to the mediastinal lymph nodes (MLNs), acquiring co-stimulatory molecules in the process. This emigration from the lung was followed by an accumulation of CD11b⁺CD11c^hi DCs in the trachea and lung interstitium. In the MLNs, the CD11b⁺ DCs contained abundant viral nucleoprotein (NP), but these cells failed to present antigen to CD4 or CD8 T cells, whereas resident CD11b⁻CD8α⁺ DCs presented to CD8 cells, and migratory CD11b⁻CD8α⁻ DCs presented to CD4 and CD8 T cells. When lung CD11c^hi DCs and macrophages or langerin⁺CD11b⁻CD11c^hi DCs were …