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Healthcare faces the challenge to deliver high treatment quality and patient satisfaction while being cost efficient which is tackled by introducing clinical pathways to standardize the treatment processes. At the Jena University Hospital, the clinical pathway for living donor liver transplantation was modeled using Business Process Model and Notation. A survey based on that model investigates on the transferability of this pathway to other hospitals and lists the requirements for a general model including the need for flexibility caused by differences in treatments in various hospitals. In this paper, we show an approach to tackle the requirements for such a flexible process by using the Case Management Model and Notation standard. Further, we show how case monitoring and analysis can be established by using an approach combining event processing and case management. The holistic approach is …