作者
Nripen Chanda, Ravi Shukla, Ajit Zambre, Swapna Mekapothula, Rajesh R Kulkarni, Kavita Katti, Kiran Bhattacharyya, Genevieve M Fent, Stan W Casteel, Evan J Boote, John A Viator, Anandhi Upendran, Raghuraman Kannan, Kattesh V Katti
发表日期
2011/2
期刊
Pharmaceutical research
卷号
28
页码范围
279-291
出版商
Springer US
简介
Purpose
The purpose of the present study was to explore the utilization of cinnamon-coated gold nanoparticles (Cin-AuNPs) as CT/optical contrast-enhancement agents for detection of cancer cells.
Methods
Cin-AuNPs were synthesized by a “green” procedure, and the detailed characterization was performed by physico-chemical analysis. Cytotoxicity and cellular uptake studies were carried out in normal human fibroblast and cancerous (PC-3 and MCF-7) cells, respectively. The efficacy of detecting cancerous cells was monitored using a photoacoustic technique. In vivo biodistribution was studied after IV injection of Cin-AuNPs in mice, and also a CT phantom model was generated.
Results
Biocompatible Cin-AuNPs were synthesized with high purity. Significant uptake of these gold nanoparticles was observed in PC-3 …
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N Chanda, R Shukla, A Zambre, S Mekapothula… - Pharmaceutical research, 2011