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Objective:

To delineate the role of hormone levels, menopause status, exogenous hormone use, and personal characteristics in the changing prevalence and impact of menopause symptoms.

Design:

Annual longitudinal data were from Michigan Bone Health Study enrollees aged 24 to 44 years at baseline and followed up for a 10-year period beginning in 1992. In self-administered interviews, women reported the presence of and degree of bother (values from 1= low to 8= high) for symptoms related to sexuality, vasomotor, sleep/fatigue, negative mood, hair/skin, and urinary problems. Annually, collected sera samples were analyzed for estradiol, follicle-stimulating hormone, and testosterone concentrations.

Results:

Increasing age consistently predicted the development and bother of the measured symptoms. Transition to postmenopause and higher levels of follicle-stimulating hormone were significantly predictive …