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In the current study, in order to augment the therapeutic efficacy of curcumin, thermo-sensitive biodegradable hydrogel composed of poly (ε-caprolactone-co-lactide)-b-poly (ethylene glycol)-b-poly (ε-caprolactone-co-lactide) (PCLA-PEG-PCLA) incorporating curcumin-loaded polyethylene glycol-b-polylactide (mPEG-PLA) nanopolymersome was prepared. The final objective of this study was to introduce a biodegradable thermo-responsive, injectable hydrogel that can prolong and localize therapeutic effects of curcumin. The obtained results demonstrated that the encapsulation of curcumin nanopolymersome in the thermos-sensitive hydrogel provided the sustained controlled release of the encapsulated curcumin. The rheological investigation demonstrated that the viscosity of the prepared composite hydrogel (20% copolymer solution) was low which made it intratumorally injectable. However, at physiological …