作者
Faraj L Haddad, Salonee V Patel, Ella E Doornaert, Cleusa De Oliveira, Brian L Allman, Kelly J Baines, Stephen J Renaud, Susanne Schmid
发表日期
2022/8/1
期刊
Brain, Behavior, & Immunity-Health
卷号
23
页码范围
100473
出版商
Elsevier
简介
Maternal infections during pregnancy are linked with an increased risk for disorders like Autism Spectrum Disorder and schizophrenia in the offspring. Although precise mechanisms are still unclear, clinical and preclinical evidence suggest a strong role for maternal immune activation (MIA) in the neurodevelopmental disruptions caused by maternal infection. Previously, studies using the Polyinosinic:Polycytidylic (Poly I:C) MIA preclinical model showed that cytokines like Interleukin 6 (Il6) are important mediators of MIA's effects. In this study, we hypothesized that Il15 may similarly act as a mediator of Poly I:C MIA, given its role in the antiviral immune response. To test this hypothesis, we induced Poly I:C MIA at gestational day 9.5 in wildtype (WT) and Il15−/− rat dams and tested their offspring in adolescence and adulthood. Poly I:C MIA and Il15 knockout produced both independent and synergistic effects on …
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FL Haddad, SV Patel, EE Doornaert, C De Oliveira… - Brain, Behavior, & Immunity-Health, 2022