作者
Naroa Goikoetxea-Usandizaga, Miren Bravo, Leire Egia-Mendikute, Leticia Abecia, Marina Serrano-Maciá, Rocío G Urdinguio, Marc Clos-García, Rubén Rodríguez-Agudo, Raquel Araujo-Legido, Lucía López-Bermudo, Teresa C Delgado, Sofía Lachiondo-Ortega, Irene González-Recio, Clàudia Gil-Pitarch, Ainize Peña-Cearra, Jorge Simón, Raquel Benedé-Ubieto, Silvia Ariño, Jose M Herranz, Mikel Azkargorta, Julio Salazar-Bermeo, Nuria Martí, Marta Varela-Rey, Juan M Falcón-Pérez, Óscar Lorenzo, Rubén Nogueiras, Félix Elortza, Yulia A Nevzorova, Francisco J Cubero, Domingo Saura, Luis Alfonso Martínez-Cruz, Guadalupe Sabio, Asís Palazón, Pau Sancho-Bru, Natalia Elguezabal, Mario F Fraga, Matías A Ávila, Ramón Bataller, José JG Marín, Franz Martín, María Luz Martínez-Chantar
发表日期
2023/9/1
期刊
Hepatology
卷号
78
期号
3
页码范围
878-895
出版商
LWW
简介
Background and Aims: Alcohol-associated liver disease (ALD) accounts for 70% of liver-related deaths in Europe, with no effective approved therapies. Although mitochondrial dysfunction is one of the earliest manifestations of alcohol-induced injury, restoring mitochondrial activity remains a problematic strategy due to oxidative stress. Here, we identify methylation-controlled J protein (MCJ) as a mediator for ALD progression and hypothesize that targeting MCJ may help in recovering mitochondrial fitness without collateral oxidative damage. Approach and Results: C57BL/6 mice [wild-type (Wt)] Mcj knockout and Mcj liver-specific silencing (MCJ-LSS) underwent the NIAAA dietary protocol
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N Goikoetxea-Usandizaga, M Bravo, L Egia-Mendikute… - Hepatology, 2023