作者
Amanda J Notini, Julie F McManus, Alison Moore, Mary Bouxsein, Mark Jimenez, WS Maria Chiu, Vaida Glatt, Barbara E Kream, David J Handelsman, Howard A Morris, Jeffrey D Zajac, Rachel A Davey
发表日期
2007/3
期刊
Journal of Bone and Mineral Research
卷号
22
期号
3
页码范围
347-356
出版商
John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR)
简介
The mechanism of androgen action on bone was studied in male mice with the AR deleted in mature osteoblasts. These mice had decreased trabecular bone volume associated with a decrease in trabecular number, suggesting that androgens may act directly on osteoblasts to maintain trabecular bone.
Introduction: Androgens modulate bone cell activity and are important for the maintenance of bone mass. However, the mechanisms by which they exert these actions on bone remain poorly defined. The aim of this study was to investigate the role of androgens acting through the classical androgen receptor (AR) signaling pathways (i.e., DNA‐binding dependent pathways) in osteoblasts using male mice in which exon 3 of the AR gene was deleted specifically in mature osteoblasts.
Materials and Methods: Mice with a floxed exon 3 of the AR gene were bred with Col 2.3‐cre transgenic mice, in which Cre …
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AJ Notini, JF McManus, A Moore, M Bouxsein… - Journal of Bone and Mineral Research, 2007