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Diabetes is a disease marked by elevated blood sugar levels, and the second leading cause of renal diseases and blindness worldwide. Artesunate is an antimalarial drug, that has been reported to have hypoglycemic potential, but to the best of our knowledge, much work has not been done to explore the biochemical and clinical implications of administration of artesunate on a diabetic subject. This study investigates biochemical changes in terms of oxidative status associated with oral administration of artesunate on diabetic animal model. Twenty eight male Wistar rats weighing averagely 200g were divided into four groups of seven rats each, Group A-control, B-Diabetes only, C-Artesunate only, D-Diabetes+ Artesunate. Diabetes was induced intraperitoneally, at a single dose of Alloxan (160mg/kg body weight (bw). Artesunate was administered orally in aqueous solution at 2.90 mg/kg bw on day one, and at 1.45 mg/kg bw on the subsequent 7days. Spectrophotometric technique was used for biochemical analysis in serum, kidney and liver homogenates. Aspartate amino transferase (AST) and Alanine amino transferase (ALT) activities as well as Creatinine concentration were significantly (P< 0.05) increased in group B compared with control, while group D showed a significant (P< 0.05) decrease compared with group B. Total protein concentration was significantly (P< 0.05) increased in group B compared with control, while group D showed an insignificant decrease compared with group B. Moreover, Superoxide dismutase (SOD) and Catalase (CAT) activities as well as Reduced glutathione (GSH) concentration were significantly (P< 0.05 …