作者
Carlo Briguori, Cristina Quintavalle, Francesca D'Alessio, Michael Donahue, Giuseppina Roscigno, Francesca De Micco, Amelia Focaccio, Gabriella Visconti, Luigi Del Vecchio, Rosalinda Madonna, Raffaele De Caterina, Gerolama Condorelli
发表日期
2017/10/1
期刊
International Journal of Cardiology
卷号
244
页码范围
112-118
出版商
Elsevier
简介
Background
A low number (that is, ≤ 0.0038 per 100 peripheral mononuclear cells) of circulating endothelial progenitor cells (EPC) is common in diabetic patients. Statins increase EPC levels. It is unclear whether intensity of statin therapy has a different impact on EPC levels.
Methods
Diabetic patients undergoing drug-eluting stent (DES) implantation were randomized to 1) High intensity statin therapy (atorvastatin 80 mg/day; n = 66) or 2) Moderate intensity statin therapy (atorvastatin 20 mg/day; n = 64). EPC levels were assessed at baseline, 24 h and 3 months. Endpoints assessed at 3 months were 1) changes in the proportion of patients with low EPC levels, and 2) uncovered struts rate and neointima growth evaluated by optical coherence tomography.
Results
Low EPC levels rate significantly decreased in the High intensity statin therapy group (from 31.7% to 12.7%; p = 0.017) but not in the Moderate intensity …
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C Briguori, C Quintavalle, F D'Alessio, M Donahue… - International Journal of Cardiology, 2017
