作者
Yvonne Döring, Oliver Soehnlein, Christian Weber
发表日期
2017/2/17
来源
Circulation research
卷号
120
期号
4
页码范围
736-743
出版商
Lippincott Williams & Wilkins
简介
Neutrophil extracellular traps expelled from suicidal neutrophils comprise a complex structure of nuclear chromatin and proteins of nuclear, granular, and cytosolic origin. These net-like structures have also been detected in atherosclerotic lesions and arterial thrombi in humans and mice. Functionally, neutrophil extracellular traps have been shown to induce activation of endothelial cells, antigen-presenting cells, and platelets, resulting in a proinflammatory immune response. Overall, this suggests that they are not only present in plaques and thrombi but also they may play a causative role in triggering atherosclerotic plaque formation and arterial thrombosis. This review will focus on current findings of the involvement of neutrophil extracellular traps in atherogenesis and atherothrombosis.
学术搜索中的文章
Y Döring, O Soehnlein, C Weber - Circulation research, 2017