作者
Jaw-Ching Wu, Yi-Hsiang Huang, Gar-Yang Chau, Chien-Wei Su, Chung-Ru Lai, Pui-Ching Lee, Teh-Ia Huo, I-Jane Sheen, Shou-Dong Lee, Wing-Yiu Lui
发表日期
2009/11/1
期刊
Journal of hepatology
卷号
51
期号
5
页码范围
890-897
出版商
Elsevier
简介
BACKGROUND/AIMS
Hepatitis B virus (HBV) levels correlate with the development of hepatocellular carcinoma (HCC), but the role of viral load in HCC recurrence after tumor resection remains unclear. Herein we aimed to investigate the role of viral load in HCC recurrence following tumor resection.
METHODS
From 1990 to 2002, 193 HBV-related HCC patients who underwent tumor resection in Taipei Veterans General Hospital were enrolled. Serum HBV DNA level and mutations were analyzed for association with early and late recurrence, together with other clinical variables.
RESULTS
During a follow-up of 58.2±44 months, 134 patients had HCC recurrence. Multivariate analysis showed that multinodularity (Hazard ratio [HR], 95% confidence interval [CI]; 2.232, 1.021–4.878), macroscopic venous invasion (4.693, 1.645–13.391), AFP >20ng/ml (3.891, 1.795–8.475), and cut margin ⩽1cm (3.333, 1.487–7.470 …
引用总数
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JC Wu, YH Huang, GY Chau, CW Su, CR Lai, PC Lee… - Journal of hepatology, 2009