作者
Paola Massari, Roberto Manetti, Daniela Burroni, Sandra Nuti, Nathalie Norais, Rino Rappuoli, John L Telford
发表日期
1998/8/1
期刊
Infection and immunity
卷号
66
期号
8
页码范围
3981-3984
出版商
American Society for Microbiology
简介
The vacuolating cytotoxin of Helicobacter pylori, VacA, enters the cytoplasm of target cells and causes vacuolar degeneration by interfering with late stages of endocytosis. By using indirect immunofluorescence and flow cytometry, we have demonstrated that VacA binds to specific high-affinity cell surface receptors and that this interaction is necessary for cell intoxication.
引用总数
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P Massari, R Manetti, D Burroni, S Nuti, N Norais… - Infection and immunity, 1998