作者
Gerald Raverot, Anne Wierinckx, Emmanuelle Dantony, Carole Auger, Guillaume Chapas, Laurent Villeneuve, Thierry Brue, Dominique Figarella-Branger, Pascal Roy, Emmanuel Jouanneau, Michel Jan, Joel Lachuer, Jacqueline Trouillas, members of HYPOPRONOS
发表日期
2010/4/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
95
期号
4
页码范围
1708-1716
出版商
Oxford University Press
简介
Context and Objective: Predicting pituitary tumor behavior remains a challenge. This multiparameter investigation aimed to identify markers for recurrence and progression in prolactin tumors.
Design: From a cohort of patients treated for prolactin tumors by surgery, we retrospectively studied clinical data, tumor characteristics, clinical outcome, and the expression of nine genes by quantitative RT-PCR.
Results: This study included 94 patients (62 females and 32 men), with long postoperative follow-up periods (mean, 138 ± 46 months); 54.3% of patients had a macro or giant adenoma. Tumors were classified into three pathological groups based on their radiological and histological characteristics (noninvasive, 61; invasive, 22; and aggressive-invasive, 11). Immediately after surgery, 60 patients (63.8%) went into remission (prolactin level normalization). Persistently elevated prolactin …
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G Raverot, A Wierinckx, E Dantony, C Auger, G Chapas… - The Journal of Clinical Endocrinology & Metabolism, 2010