作者
Daniela D'Angelo, Dario Palmieri, Paula Mussnich, Magali Roche, Anne Wierinckx, Gerald Raverot, Monica Fedele, Carlo Maria Croce, Jacqueline Trouillas, Alfredo Fusco
发表日期
2012/7/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
97
期号
7
页码范围
E1128-E1138
出版商
Oxford University Press
简介
Context
MicroRNA (miRNA) are an important class of regulators of gene expression. Altered miRNA expression has been constantly found in human neoplasias and plays an important role in the process of carcinogenesis.
Objective
The aim of this study was to identify specific miRNA whose expression is altered in GH-secreting pituitary adenomas.
Design
Using a miRNACHIP microarray, we have analyzed the miRNA expression profile of human GH adenomas vs. normal pituitary gland.
Results
We report the identification of a set of miRNA, including miR-34b, miR-326, miR-432, miR-548c-3p, miR-570, and miR-603, drastically and constantly down-regulated in GH adenomas. We demonstrate that these miRNA target genes such as high-mobility group A1 (HMGA1), HMGA2, and E2F1, whose overexpression and/or activation plays a …
学术搜索中的文章
D D'Angelo, D Palmieri, P Mussnich, M Roche… - The Journal of Clinical Endocrinology & Metabolism, 2012
