作者
Adrian F Daly, Maria A Tichomirowa, Patrick Petrossians, Elina Heliovaara, Marie-Lise Jaffrain-Rea, Anne Barlier, Luciana A Naves, Tapani Ebeling, Auli Karhu, Antti Raappana, Laure Cazabat, Ernesto De Menis, Carmen Fajardo Montañana, Gerald Raverot, Robert J Weil, Timo Sane, Dominique Maiter, Sebastian Neggers, Maria Yaneva, Antoine Tabarin, Elisa Verrua, Eija Eloranta, Arnaud Murat, Outi Vierimaa, Pasi I Salmela, Philippe Emy, Rodrigo A Toledo, Maria Isabel Sabaté, Chiara Villa, Marc Popelier, Roberto Salvatori, Juliet Jennings, Ángel Ferrandez Longás, Jose Ignacio Labarta Aizpun, Marianthi Georgitsi, Ralf Paschke, Cristina Ronchi, Matti Valimaki, Carola Saloranta, Wouter De Herder, Renato Cozzi, Mirtha Guitelman, Flavia Magri, Maria Stefania Lagonigro, Georges Halaby, Vinciane Corman, Marie-Therese Hagelstein, Jean-Francois Vanbellinghen, Gustavo Barcelos Barra, Anne-Paule Gimenez-Roqueplo, Fergus J Cameron, Francoise Borson-Chazot, Ian Holdaway, Sergio PA Toledo, Günter K Stalla, Anna Spada, Sabina Zacharieva, Jerome Bertherat, Thierry Brue, Vincent Bours, Philippe Chanson, Lauri A Aaltonen, Albert Beckers
发表日期
2010/11/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
95
期号
11
页码范围
E373-E383
出版商
Oxford University Press
简介
Context: AIP mutations (AIPmut) give rise to a pituitary adenoma predisposition that occurs in familial isolated pituitary adenomas and less often in sporadic cases. The clinical and therapeutic features of AIPmut-associated pituitary adenomas have not been studied comprehensively.
Objective: The objective of the study was to assess clinical/therapeutic characteristics of AIPmut pituitary adenomas.
Design: This study was an international, multicenter, retrospective case collection/database analysis.
Setting: The study was conducted at 36 tertiary referral endocrine and clinical genetics departments.
Patients: Patients included 96 patients with germline AIPmut and pituitary adenomas and 232 matched AIPmut-negative acromegaly controls.
Results: The AIPmut population was predominantly young and male (63.5%); first symptoms occurred as children …
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AF Daly, MA Tichomirowa, P Petrossians, E Heliovaara… - The Journal of Clinical Endocrinology & Metabolism, 2010
