作者
Nadja Van Camp, Raphael Boisgard, Bertrand Kuhnast, Benoit Thézé, Thomas Viel, Marie-Claude Grégoire, Fabien Chauveau, Hervé Boutin, Andrew Katsifis, Frédéric Dollé, Bertrand Tavitian
发表日期
2010/5
期刊
European journal of nuclear medicine and molecular imaging
卷号
37
页码范围
962-972
出版商
Springer-Verlag
简介
Purpose
The key role of neuroinflammation in acute and chronic neurological disorders has stimulated the search for specific radiotracers targeting the peripheral benzodiazepine receptor (PBR)/18 kDa translocator protein (TSPO), a hallmark of neuroinflammation. Here we evaluate the new radiotracer for positron emission tomography (PET) [18F]PBR111 in a rodent model of acute inflammation and compare it with [11C]CLINME, an 11C-labelled tracer of the same chemical family, and with the isoquinolinic carboxamide [11C]PK11195.
Methods
We studied radiometabolites by HPLC, in vitro binding by autoradiography and in vivo brain kinetics as well as in vivo specificity of binding using PET imaging.
Results
We show that this radiotracer has a high in vitro specificity for PBR/TSPO versus central benzodiazepine …
学术搜索中的文章
N Van Camp, R Boisgard, B Kuhnast, B Thézé, T Viel… - European journal of nuclear medicine and molecular …, 2010