作者
Fabien Chauveau, Hervé Boutin, Nadja Van Camp, Cyrille Thominiaux, Philippe Hantraye, Luc Rivron, Frank Marguet, Marie-Noëlle Castel, Thomas Rooney, Jesus Benavides, Frédéric Dollé, Bertrand Tavitian
发表日期
2011/3
期刊
European journal of nuclear medicine and molecular imaging
卷号
38
页码范围
509-514
出版商
Springer-Verlag
简介
Purpose
Neuroinflammation is involved in neurological disorders through the activation of microglial cells. Imaging of neuroinflammation with radioligands for the translocator protein (18 kDa) (TSPO) could prove to be an attractive biomarker for disease diagnosis and therapeutic evaluation. The indoleacetamide-derived 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, SSR180575, is a selective high-affinity TSPO ligand in human and rodents with neuroprotective effects.
Methods
Here we report the radiolabelling of SSR180575 with 11C and in vitro and in vivo imaging in an acute model of neuroinflammation in rats.
Results
The image contrast and the binding of [11C]SSR180575 are higher than that obtained with the isoquinoline-based TSPO radioligand, [11C]PK11195 …
学术搜索中的文章
F Chauveau, H Boutin, N Van Camp, C Thominiaux… - European journal of nuclear medicine and molecular …, 2011