作者
Laila M Sherief, Ahmad G Kamal, EA Khalek, Naglaa M Kamal, Attia AA Soliman, Asmaa M Esh
发表日期
2012/5/1
期刊
Hematology
卷号
17
期号
3
页码范围
151-156
出版商
Taylor & Francis
简介
Background
The main strategy for minimizing anthracycline cardiotoxicity is early detection of high-risk patients.
Aim of the study
To investigate the role of cardiac biomarkers; cardiac troponin T (cTnT) and N-terminal probrain natriuretic peptide (NT-pro-BNP), and tissue Doppler imaging (TDI), as early predictors of chronic cardiotoxicity in survivors of acute leukemia.
Patients and methods
We carried a retrospective study on 50 asymptomatic survivors of acute leukemia who received anthracycline in their treatment protocols. All patients underwent blood sampling to determine the levels of NT-pro-BNP and cTnT along with conventional echocardiography and TDI.
Results
None had abnormal cTnT levels. About 20% had abnormal NT-pro-BNP levels. Diastolic dysfunction of the left ventricle was the most significant in conventional echocardiography. TDI was superior as it detected myocardial affection in 10% more than …
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LM Sherief, AG Kamal, EA Khalek, NM Kamal… - Hematology, 2012