作者
Stacy S Drury, Katherine Theall, Mary M Gleason, Anna T Smyke, Immaculata De Vivo, JYY Wong, Nathan A Fox, Charles H Zeanah, Charles A Nelson
发表日期
2012/7
期刊
Molecular psychiatry
卷号
17
期号
7
页码范围
719-727
出版商
Nature Publishing Group
简介
Accelerated telomere length attrition has been associated with psychological stress and early adversity in adults; however, no studies have examined whether telomere length in childhood is associated with early experiences. The Bucharest Early Intervention Project is a unique randomized controlled trial of foster care placement compared with continued care in institutions. As a result of the study design, participants were exposed to a quantified range of time in institutional care, and represented an ideal population in which to examine the association between a specific early adversity, institutional care and telomere length. We examined the association between average relative telomere length, telomere repeat copy number to single gene copy number (T/S) ratio and exposure to institutional care quantified as the percent of time at baseline (mean age 22 months) and at 54 months of age that each child lived in …
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