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Coronavirus disease 2019 (COVID-19) is a viral respiratory disease that mysteriously emerged in late December 2019 in Wuhan City, China. The virus quickly spread worldwide and was announced a global pandemic by the World Health Organization in March 2020. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread around the world, as of late July 2020, over 17 million people had been infected, causing over 665,000 deaths and these numbers continued to trend upwards. Prior to the antibiotic era, serum therapy was widely used to treat a range of infectious diseases such as scarlet fever and pneumococcal pneumonia. Convalescent plasma with neutralizing antibodies is currently being used for investigational purposes in the COVID-19 pandemic, and preliminary results from 2 small studies performed in China are encouraging.