作者
Kelly Ishida, Juliany Cola Fernandes Rodrigues, Marcos Dornelas Ribeiro, Taíssa Vieira Machado Vila, Wanderley de Souza, Julio A Urbina, Celso Vataru Nakamura, Sonia Rozental
发表日期
2009/12
期刊
BMC microbiology
卷号
9
页码范围
1-12
出版商
BioMed Central
简介
Background
Although Candida species are commensal microorganisms, they can cause many invasive fungal infections. In addition, antifungal resistance can contribute to failure of treatment.
The purpose of this study was to evaluate the antifungal activity of inhibitors of Δ24(25)-sterol methyltransferase (24-SMTI), 20-piperidin-2-yl-5α-pregnan-3β-20(R)-diol (AZA), and 24(R,S),25-epiminolanosterol (EIL), against clinical isolates of Candida spp., analysing the ultrastructural changes.
Results
AZA and EIL were found to be potent growth inhibitors of Candida spp. isolates. The median MIC50 was 0.5 μg.ml-1 for AZA and 2 μg.ml-1 for EIL, and the MIC90 was 2 μg.ml-1 for both compounds. All strains used in this study were susceptible to amphotericin B; however, some isolates were fluconazole- and itraconazole-resistant. Most of the azole-resistant …
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K Ishida, JCF Rodrigues, MD Ribeiro, TVM Vila… - BMC microbiology, 2009