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Objectives: The main aim of the study is to evaluate the effectiveness of an educational program on nurses’ knowledge concerning side effect of radiotherapy

Methodology: Quiz experimental study was carried out at Al Amal National Hospital for Cancer Management from 4th, November 2013 to 29th August, 2014. The program and instruments were constructed by the researcher for the purpose of the study. Purposive random sample comprised of (60) nurses was divided into two groups, study group consisted of (30) nurses exposed to the nursing educational program and control group consisted of (30) nurses were not exposed to the program. The measurement of effectiveness of nursing educational program through the nurse s’ nowledge questionnaire includes (30) items concerning side effect of radiotherapy.