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Porosity is an important factor in the healing of prosthetic devices. To better understand this phenomenon, porous polyurethane scaffolds were produced by a variation of the phase inversion/porogen extraction technique in which a prepacked column of spherical porogen particles was infiltrated with a polymer solution before polymer precipitation and porogen extraction. Scaffolds contained pores of well defined shape (approaching open faced pentagonal dodecahedra), narrow size distributions (66.1±1.3 μm, 84.2±1.7 μm, and 156.9±1.2 μm) and high interconnectivity (interconnecting windows of 30.1±0.8 μm, 41.9±1.5 μm, and 76.4±2.0 μm, respectively). A high degree of accessible macroporosity (> 80%) could be achieved while limiting the mostly inaccessible microporosity to below 2%.