作者
Sarah L Olguin, Shannon M Thompson, Jared W Young, Jonathan L Brigman
发表日期
2021/1
期刊
Genes, Brain and Behavior
卷号
20
期号
1
页码范围
e12652
出版商
Blackwell Publishing Ltd
简介
A common feature associated with fetal alcohol spectrum disorders is the inability to concentrate on a specific task while ignoring distractions. Human continuous performance tasks (CPT), measure vigilance and cognitive control simultaneously while these processes are traditionally measured separately in rodents. We recently established a touchscreen 5‐choice CPT (5C‐CPT) that measures vigilance and cognitive control simultaneously by incorporating both target and nontargets and showed it was sensitive to amphetamine‐induced improvement in humans and mice. Here, we examined the effects of moderate prenatal alcohol exposure (PAE) in male and female mice on performance of the 5‐choice serial reaction time task (5‐CSRTT), which contained only target trials, and the 5C‐CPT which incorporated both target and nontarget trials. In addition, we assessed gait and fine motor coordination in behavioral …
引用总数
20202021202220232024448101