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Objectives. The purpose of this study was to test the hypothesis that the reduction of body iron stores by venesection (blood letting) would reduce the susceptibility to oxidation of atherogenic serum lipoproteins.

Design. This is a randomized, controlled cross‐over trial in 14 regularly smoking men with elevated serum ferritin concentration. The study design comprised two 14‐week study periods, with a 14‐week wash‐out period in between, with either blood donations or control.

Setting. The study site was the Research Institute of Public Health, University of Kuopio. Investigators from the Division of Epidemiology, University of Minnesota, Minneapolis, participated in the planning of the study.

Subjects. Fourteen volunteers who were heavy smokers and had previous experience in blood letting were recruited for the study.

Interventions. During the intervention periods, the subjects donated 450 mg (500 mL) of blood …