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Tomato (Solanum lycopersicum L.) plants are considered sensitive to tomato mosaic virus especially during the reproductive growth phase. Hence, the present study aimed to investigate the effect of foliar application with salicylic acid (2 mM/l) alone or combined with chitosan (0.1%) with or without TMV inoculation on improving resistance, growth, productivity and quality of tomato Hybrid Super Jackal F. The 1 study was conducted in The Experimental Farm, Faculty of Agriculture, Ain Shams University, Shoubra El-Kheima, Egypt, during the two growing summer seasons of 2012 and 2013. All inoculated plants with TMV after 14 and 30 days from foliar application with combination of salicylic acid and chitosan, exhibited symptoms later and less severe than the plants inoculated with TMV in the other treatments. The SA plus CH foliar application without TMV inoculation gave the highest significant values of vegetative growth in both seasons. Combination treatment of SA plus CH increased significantly N, P, K, Fe and Zn concentration. This treatment was also effective in increasing tomato yield compared with treatment of infection alone. Our results showed that SA or CH alone or combined significantly increased ascorbic acid concentration compared with control treatment.