作者
Sharon Conroy, Imti Choonara, Piero Impicciatore, Angelika Mohn, Henrik Arnell, Anders Rane, Carmen Knoeppel, Hannsjoerg Seyberth, Chiara Pandolfini, Maria Pia Raffaelli, Francesca Rocchi, Maurizio Bonati, Matthijs de Hoog, John van den Anker
发表日期
2000/1/8
期刊
bmj
卷号
320
期号
7227
页码范围
79-82
出版商
British Medical Journal Publishing Group
简介
Objective: To determine the extent of use of unlicensed and off label drugs in children in hospital in five European countries.
Design: Prospective study of drugs administered to children in general paediatric medical wards over four weeks.
Setting: Children's wards in five hospitals (one each in the United Kingdom, Sweden, Germany, Italy, and the Netherlands).
Subjects: Children aged 4 days to 16 years admitted to general paediatric medical wards.
Main outcome measure: Proportion of drugs that were used in an unlicensed or off label manner.
Results: 2262 drug prescriptions were administered to 624 children in the five hospitals. Almost half of all drug prescriptions (1036; 46%) were either unlicensed or off label. Of these 1036, 872 were off label and 164 were unlicensed. Over half of the patients (421; 67%) received an unlicensed or off label drug prescription.
Conclusions: Use of off label or unlicensed drugs to …
引用总数
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S Conroy, I Choonara, P Impicciatore, A Mohn, H Arnell… - bmj, 2000
