作者
Nicola Filippini, Eniko Zsoldos, Rita Haapakoski, Claire E Sexton, Abda Mahmood, Charlotte L Allan, Anya Topiwala, Vyara Valkanova, Eric J Brunner, Martin J Shipley, Edward Auerbach, Steen Moeller, U Kâmil, Junqian Xu, Essa Yacoub, Jesper Andersson, Janine Bijsterbosch, Stuart Clare, Ludovica Griffanti, Aaron T Hess, Mark Jenkinson, Karla L Miller, Gholamreza Salimi-Khorshidi, Stamatios N Sotiropoulos, Natalie L Voets, Stephen M Smith, John R Geddes, Archana Singh-Manoux, Clare E Mackay, Mika Kivimäki, Klaus P Ebmeier
发表日期
2014/5/30
期刊
BMC psychiatry
卷号
14
期号
1
页码范围
159
出版商
BioMed Central Ltd
简介
Background
The Whitehall II (WHII) study of British civil servants provides a unique source of longitudinal data to investigate key factors hypothesized to affect brain health and cognitive ageing. This paper introduces the multi-modal magnetic resonance imaging (MRI) protocol and cognitive assessment designed to investigate brain health in a random sample of 800 members of the WHII study.
Methods/design
A total of 6035 civil servants participated in the WHII Phase 11 clinical examination in 2012–2013. A random sample of these participants was included in a sub-study comprising an MRI brain scan, a detailed clinical and cognitive assessment, and collection of blood and buccal mucosal samples for the characterisation of immune function and associated measures. Data collection for this sub-study started in 2012 and will be completed by 2016. The …
学术搜索中的文章
N Filippini, E Zsoldos, R Haapakoski, CE Sexton… - BMC psychiatry, 2014