作者
Claire Green, Xueyi Shen, Anna J Stevenson, Eleanor LS Conole, Mathew A Harris, Miruna C Barbu, Emma L Hawkins, Mark J Adams, Robert F Hillary, Stephen M Lawrie, Kathryn L Evans, Rosie M Walker, Stewart W Morris, David J Porteous, Joanna M Wardlaw, J Douglas Steele, Gordon D Waiter, Anca-Larisa Sandu, Archie Campbell, Riccardo E Marioni, Simon R Cox, Jonathan Cavanagh, Andrew M McIntosh, Heather C Whalley
发表日期
2021/2/1
期刊
Brain, behavior, and immunity
卷号
92
页码范围
39-48
出版商
Academic Press
简介
Inflammatory processes are implicated in the aetiology of Major Depressive Disorder (MDD); however, the relationship between peripheral inflammation, brain structure and depression remains unclear, partly due to complexities around the use of acute/phasic inflammatory biomarkers.
Here, we report the first large-scale study of both serological and methylomic signatures of CRP (considered to represent acute and chronic measures of inflammation respectively) and their associations with depression status/symptoms, and structural neuroimaging phenotypes (T1 and diffusion MRI) in a large community-based sample (Generation Scotland; NMDD cases = 271, Ncontrols = 609).
Serum CRP was associated with overall MDD severity, and specifically with current somatic symptoms- general interest (β = 0.145, PFDR = 6 × 10−4) and energy levels (β = 0.101, PFDR = 0.027), along with reduced entorhinal cortex …
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