作者
Catherine Tcheandjieu, Xiang Zhu, Austin T Hilliard, Shoa L Clarke, Valerio Napolioni, Shining Ma, Kyung Min Lee, Huaying Fang, Fei Chen, Yingchang Lu, Noah L Tsao, Sridharan Raghavan, Satoshi Koyama, Bryan R Gorman, Marijana Vujkovic, Derek Klarin, Michael G Levin, Nasa Sinnott-Armstrong, Genevieve L Wojcik, Mary E Plomondon, Thomas M Maddox, Stephen W Waldo, Alexander G Bick, Saiju Pyarajan, Jie Huang, Rebecca Song, Yuk-Lam Ho, Steven Buyske, Charles Kooperberg, Jeffrey Haessler, Ruth JF Loos, Ron Do, Marie Verbanck, Kumardeep Chaudhary, Kari E North, Christy L Avery, Mariaelisa Graff, Christopher A Haiman, Loic Le Marchand, Lynne R Wilkens, Joshua C Bis, Hampton Leonard, Botong Shen, Leslie A Lange, Ayush Giri, Ozan Dikilitas, Iftikhar J Kullo, Ian B Stanaway, Gail P Jarvik, Adam S Gordon, Scott Hebbring, Bahram Namjou, Kenneth M Kaufman, Kaoru Ito, Kazuyoshi Ishigaki, Yoichiro Kamatani, Shefali S Verma, Marylyn D Ritchie, Rachel L Kember, Aris Baras, Luca A Lotta, Regeneron Genetics Center, CARDIoGRAMplusC4D Consortium, Biobank Japan, Million Veteran Program, Sekar Kathiresan, Elizabeth R Hauser, Donald R Miller, Jennifer S Lee, Danish Saleheen, Peter D Reaven, Kelly Cho, J Michael Gaziano, Pradeep Natarajan, Jennifer E Huffman, Benjamin F Voight, Daniel J Rader, Kyong-Mi Chang, Julie A Lynch, Scott M Damrauer, Peter WF Wilson, Hua Tang, Yan V Sun, Philip S Tsao, Christopher J O’Donnell, Themistocles L Assimes
发表日期
2022/8
期刊
Nature medicine
卷号
28
期号
8
页码范围
1679-1692
出版商
Nature Publishing Group US
简介
We report a genome-wide association study (GWAS) of coronary artery disease (CAD) incorporating nearly a quarter of a million cases, in which existing studies are integrated with data from cohorts of white, Black and Hispanic individuals from the Million Veteran Program. We document near equivalent heritability of CAD across multiple ancestral groups, identify 95 novel loci, including nine on the X chromosome, detect eight loci of genome-wide significance in Black and Hispanic individuals, and demonstrate that two common haplotypes at the 9p21 locus are responsible for risk stratification in all populations except those of African origin, in which these haplotypes are virtually absent. Moreover, in the largest GWAS for angiographically derived coronary atherosclerosis performed to date, we find 15 loci of genome-wide significance that robustly overlap with established loci for clinical CAD. Phenome-wide …
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C Tcheandjieu, X Zhu, AT Hilliard, SL Clarke… - Nature medicine, 2022