作者
Lin Gan, Mengqing Xiang, Lijuan Zhou, Daniel S Wagner, William H Klein, Jeremy Nathans
发表日期
1996/4/30
期刊
Proceedings of the National Academy of Sciences
卷号
93
期号
9
页码范围
3920-3925
出版商
National Acad Sciences
简介
The three members of the Brn-3 family of POU domain transcription factors are found in highly restricted sets of central nervous system neurons. Within the retina, these factors are present only within subsets of ganglion cells. We show here that in the developing mouse retina, Brn-3b protein is first observed in presumptive ganglion cell precursors as they begin to migrate from the zone of dividing neuroblasts to the future ganglion cell layer, and that targeted disruption of the Brn-3b gene leads in the homozygous state to a selective loss of 70% of retinal ganglion cells. In Brn-3b (-/-) mice other neurons within the retina and brain are minimally or not at all affected. These experiments indicate that Brn-3b plays an essential role in the development of specific ganglion cell types.
引用总数
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L Gan, M Xiang, L Zhou, DS Wagner, WH Klein… - Proceedings of the National Academy of Sciences, 1996