作者
Young Suk Jo, Shengjin Li, Jung Hun Song, Ki Hyun Kwon, Jun Chul Lee, So Young Rha, Hyo Jin Lee, Ji Young Sul, Gi Ryang Kweon, Heung-kyu Ro, Jin-Man Kim, Minho Shong
发表日期
2006/9/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
91
期号
9
页码范围
3667-3670
出版商
Oxford University Press
简介
Context: The BRAF mutation may influence the expression patterns of molecular markers that are related to the development and progression of thyroid cancer.
Objective: The objective of the study was to investigate the effects of the BRAF V600E mutation on expression of galectin-3, cyclooxygenase-2, cyclin D1, p53, and vascular endothelial growth factor (VEGF) in papillary thyroid cancer (PTC).
Design, Setting, and Subjects: One hundred sixty-three PTC and 28 nodular hyperplasia patients were selected retrospectively. The presence of the BRAF V600E mutation and the level of expression of the molecular markers were determined.
Results: Of 161 PTC patients, 102 patients (63.4%) were BRAF V600E(+), and these cases had significantly larger tumor sizes (P = 0.01), compared with V600E(−) cases (n = 59, 36.6%). Although PTC tissues had higher expression levels …
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YS Jo, S Li, JH Song, KH Kwon, JC Lee, SY Rha… - The Journal of Clinical Endocrinology & Metabolism, 2006