作者
Chiara Villa, Chiara Fenoglio, Milena De Riz, Francesca Clerici, Alessandra Marcone, Luisa Benussi, Roberta Ghidoni, Salvatore Gallone, Francesca Cortini, Maria Serpente, Claudia Cantoni, Giorgio Fumagalli, Filippo Martinelli Boneschi, Stefano Cappa, Giuliano Binetti, Massimo Franceschi, Innocenzo Rainero, Maria Teresa Giordana, Claudio Mariani, Nereo Bresolin, Elio Scarpini, Daniela Galimberti
发表日期
2011/6/1
期刊
Rejuvenation research
卷号
14
期号
3
页码范围
275-281
出版商
Mary Ann Liebert, Inc.
简介
An association study of heterogeneous nuclear ribonucleoprotein (hnRNP)-A1 was carried out in a population of 274 patients with frontotemporal lobar degeneration (FTLD) and 287 with Alzheimer disease (AD) as compared with 344 age- and gender-matched controls. In addition, we evaluated expression levels of hnRNP-A1 and its regulatory microRNA (miR)-590-3p in blood cells from patients and controls. A statistically significant increased frequency of the hnRNP-A1 rs7967622 C/C genotype was observed in FTLD, but not in AD, in patients as compared to controls (23.0 versus 15.4%; p = 0.022, odds ratio [OR] 1.64, confidence interval [CI] 1.09–2.46). Stratifying according to gender, a statistically significant increased frequency of the hnRNP-A1 rs7967622 C/C genotype was observed in male patients as compared to male controls (23.1 versus 11.3%; p = 0.015, OR 2.36, CI 1.22–4.58 but not in females …
学术搜索中的文章
C Villa, C Fenoglio, M De Riz, F Clerici, A Marcone… - Rejuvenation research, 2011
