作者
David J Lederer, Steven M Kawut, Nancy Wickersham, Christopher Winterbottom, Sangeeta Bhorade, Scott M Palmer, James Lee, Joshua M Diamond, Keith M Wille, Ann Weinacker, Vibha N Lama, Maria Crespo, Jonathan B Orens, Joshua R Sonett, Selim M Arcasoy, Lorraine B Ware, Jason D Christie
发表日期
2011/11/1
期刊
American journal of respiratory and critical care medicine
卷号
184
期号
9
页码范围
1055-1061
出版商
American Thoracic Society
简介
Rationale: Obesity has been linked to acute lung injury and is a risk factor for early mortality after lung transplantation.
Objectives: To examine the associations of obesity and plasma adipokines with the risk of primary graft dysfunction after lung transplantation.
Methods: We performed a prospective cohort study of 512 adult lung transplant recipients with chronic obstructive pulmonary disease or interstitial lung disease enrolled in the Lung Transplant Outcomes Group Study. In a nested case-control study, we measured plasma leptin, adiponectin, and resistin before lung transplantation and 6 and 24 hours after lung transplantation in 40 cases of primary graft dysfunction and 80 control subjects. Generalized linear mixed models and logistic regression were used to estimate risk ratios and odds ratios.
Measurements and Main Results: Grade 3 primary graft dysfunction developed within 72 hours of transplantation in 29 …
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DJ Lederer, SM Kawut, N Wickersham, C Winterbottom… - American journal of respiratory and critical care …, 2011